Myocardial homing of mesenchymal stem cells following intrapericardial application and amplification by inflammation - an experimental pilot study.

نویسندگان

  • Nina Jung
  • Heinz Rupp
  • A Rembert Koczulla
  • Claus F Vogelmeier
  • Peter Alter
چکیده

Recent studies demonstrated potential effects of stem cells on cardiac function in heart failure. However, influences of the technique of application remained undetermined. In the present study, the pericardial sac was used as depot for fluorescent-labeled mesenchymal stem cells in rats. To evaluate influences of inflammation on cell homing, a sterile pericarditis was induced by talc. It is shown that intrapericardial stem cell application is sufficient to provide myocardial penetration. The extent of homing was amplified by inflammation in a talc-induced pericarditis.

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عنوان ژورنال:
  • Canadian journal of physiology and pharmacology

دوره 95 9  شماره 

صفحات  -

تاریخ انتشار 2017